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Dallas
Granite Park Three
5601 Granite Parkway, Suite 750
Plano, Texas 75024
972.731.2288 Phone
972.731.2289 Fax |
Education
Ph.D., Chemistry, 1998
University of California, Santa Barbara (Chemistry)
B.S., Chemistry, 1989
California State University, Bakersfield
Jerry V. Walker has expertise in the areas of inorganic and
bioinorganic chemistry, molecular biology, enzymology, protein
purification, computational biology, gene therapy and structural
biology.
Before joining the firm, Dr. Walker
was a postdoctoral research associate in the Department of
Molecular Pharmacology at St. Jude Children’s Research
Hospital where her research centered on elucidating mechanisms
of drug action with an aim of designing new and more therapeutically
effective anticancer and antibacterial agents. Specifically,
Dr. Walker’s research focused on the mechanism of action
of anti-topoisomerase targeting drugs by evaluating mutations
in topoisomerase II utilizing yeast model systems. Dr. Walker’s
graduate research was in the area of marine bioinorganic chemistry
with an emphasis on transition metal catalysts. Dr. Walker
was also a UNCF-MERCK postdoctoral research award recipient.
Recent Publications
1. Vaughn J, Huang S, Wessel I, Sorensen TK, Hsieh T, Jensen
LH, Jensen PB, Sehested M, Nitiss JLL. "Stability
of the topoisomerase II closed clamp conformation may influence
DNA stimulated ATP hydrolysis," J Biol Chem. 2005,
Jan 12.
2. Walker J, Nitiss KC, Jensen L, Mayne C, Hu T, Jensen PB,
Sehested M, Hsieh T, Nitiss JL. "A mutation human
topoisomerase II a whose expression is lethal in DNA repair
deficient yeast cells," J Biol Chem. 2004 Jun 18;
279(25): 25947-54.
3. Strumberg,D. Nitiss,JL. Dong,J. Walker, J. Nicklaus,MC.
Kohn,KW., Heddle,JG. Maxwell,A. Pommier,Y. "Importance
of the fourth alpha-helix within the cap homology domain of
type II topoisomerase for DNA cleavage site recognition and
quinolone action,"Antimicrob. Agents Chemother.
46:2735-2746,2002.
4. Walker,JV. and Nitiss, JL. "DNA Topoiosmerase
II as a target for cancer chemotherapy,"Cancer Investigation.
240:570-89,2002.
5. Dong, J. Walker,J. Nitiss, JL. "A mutation in
yeast topoisomerase II that confers hypersensitivity to multiple
classes of topoisomerase II poisons,"J. Biol. Chem.
2000 275: 7980-7987.
6. Walker JV, Morey M, Carlsson H, Davidson A, Stucky GD,
Butler A. " Peroxidative halogenation catalyzed by
transition-metal-ion-grafted mesoporous silicate materials,"J
Am Chem Soc 119:6921-6922, 1997.
7. Walker JV, Butler A. "Vanadium bromoperoxidase
catalyzed oxidation of thiocyanate," Inorgan Chim
Acta 243:201-206, 1996.
8. Sodejak HS, Walker JV, Butler A. "Inhibition and
inactivation of vanadium bromoperoxidase by the substrate
hydrogen peroxide and further mechanistic studies of vanadium
bromoperoxidase,"Biochemistry 34:12689-12696, 1995.
9. Butler A, Walker JV. "Marine haloperoxidases,"Chem.
Rev 93:1937-1944, 1993.
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